Indication
Prioritization
Prioritization
PandaOmics enables users to prioritize therapeutic areas and specific indications for a given target.
The Indication Prioritization heatmap can be found on the dedicated tab of the Gene page. Precalculated scores allow users can get a ranked list of indications and therapeutic areas for a given target and identify potential candidates for expanding indications or exploring new applications.
Calculation of the Scores
Indication Prioritization offers precalculated scores for over 7,000 indications, derived from text, financial, and omics data. Just like the Target ID and Compound ID pages, the calculated scores are displayed as a heatmap, with indications listed in rows and scores in columns. By default, all scores are considered when calculating the disease rank. Users have the ability to adjust the parameters of Indication Prioritization and customize their research requirements by selecting which specific scores are turned on. For instance, if the user aims to identify novel diseases that may be linked to the gene of interest, they may wish to turn off text-based scores to reduce the influence of existing knowledge on the ranking of indications.
Heatmap View Options
Indication prioritization is presented in different views, allowing users to observe ranked diseases in a way that suits the pharmaceutical industry's interests. The heatmap may be displayed as an Ungrouped view, or the Pathology and Tissue/Organ system views as defined by manually curated classification by the PandaOmics team.
By default, indications are grouped by Pathology groups. Clicking on disease groups will reveal a list of included indications ranked by the scores that are turned on. The scores for Pathology/ Tissue/Organ system groups are calculated based on the the scores for individual diseases within groups.
Disease groups and indications are prioritized in ascending order based on their overall rank. Within each disease group, diseases are ranked according to their overall position in the entire disease space, and only the top 100 indications for each group are displayed. Moreover, users have the option to choose other types of heatmap views, such as grouping by Organ/Tissue system or switching to the Ungrouped view, where all diseases are in one list.
By default, indications are grouped by Pathology groups. Clicking on disease groups will reveal a list of included indications ranked by the scores that are turned on. The scores for Pathology/ Tissue/Organ system groups are calculated based on the the scores for individual diseases within groups.
Disease groups and indications are prioritized in ascending order based on their overall rank. Within each disease group, diseases are ranked according to their overall position in the entire disease space, and only the top 100 indications for each group are displayed. Moreover, users have the option to choose other types of heatmap views, such as grouping by Organ/Tissue system or switching to the Ungrouped view, where all diseases are in one list.
Navigation
1
Users can interact with the heatmap by sorting indications in descending order by clicking on the top of a score column.
When working with Pathology or Tissue/Organ system views, sorting is available only for diseases inside groups. At the same time, by selecting different score combinations, users can obtain a new rank for Disease groups.
2
Clicking on a specific disease name will redirect users to the relevant Gene-Disease association page, providing further insights and context.
3
By default top-100 diseases are plotted on the heatmap, however the user can use the search box in the upper right corner to find rank and score values for a particular disease.
Search allows users to find suitable diseases by searching for the disease name, its synonyms, or EFO_ID.
Training Video